Sapporo, Hokkaido Prefecture’s largest city and capital, as seen from the ferris wheel on top of NORBESA, a shopping complex in the Susukino District. 31. The Hokkaido Region February 03, 2020 by Jason Nieling in Regions Hokkaido is the second largest main island of Japan as well as the largest and northernmost prefecture. Join Jason and Paul as they explore the nature, food, and culture of the Hokkaido region!